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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP1
All Species:
27.88
Human Site:
T680
Identified Species:
47.18
UniProt:
P11387
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11387
NP_003277.1
765
90726
T680
K
V
M
K
D
A
K
T
K
K
V
V
E
S
K
Chimpanzee
Pan troglodytes
A9Q1D5
601
69739
K523
S
R
S
V
L
E
K
K
R
R
L
L
E
K
L
Rhesus Macaque
Macaca mulatta
XP_001088021
767
90935
T682
K
V
M
K
D
A
K
T
K
K
V
V
E
S
K
Dog
Lupus familis
XP_534420
1004
115318
T919
K
V
L
K
D
A
K
T
K
K
V
V
E
S
K
Cat
Felis silvestris
Mouse
Mus musculus
Q04750
767
90857
T682
K
V
M
K
D
A
K
T
K
K
V
V
E
S
K
Rat
Rattus norvegicus
Q9WUL0
767
90741
T682
K
V
M
K
D
A
K
T
K
K
V
V
E
S
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509816
781
92543
S696
K
V
Q
R
D
A
K
S
K
K
V
V
E
T
K
Chicken
Gallus gallus
Frog
Xenopus laevis
P41512
829
98212
T736
K
V
R
R
D
E
K
T
K
K
L
V
E
S
K
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30189
972
111670
Y887
I
E
K
C
E
S
E
Y
H
S
R
D
E
K
K
Honey Bee
Apis mellifera
XP_396203
973
114099
N884
E
A
K
K
Q
A
I
N
D
A
E
L
D
S
T
Nematode Worm
Caenorhab. elegans
O17966
806
94011
K722
K
S
A
R
G
A
E
K
E
K
A
Q
K
K
Y
Sea Urchin
Strong. purpuratus
XP_793285
879
100968
L794
K
N
S
R
N
E
K
L
K
L
A
M
E
K
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30181
916
102780
G825
P
P
L
E
G
S
D
G
K
K
I
R
S
L
E
Baker's Yeast
Sacchar. cerevisiae
P04786
769
89977
E689
K
S
S
W
N
S
V
E
K
I
K
A
Q
V
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
54.1
99
74.8
N.A.
97
97
N.A.
90.4
N.A.
75
N.A.
N.A.
49.6
53.5
54.8
45.3
Protein Similarity:
100
67.4
99.6
75.8
N.A.
98.6
98.6
N.A.
93.8
N.A.
82.7
N.A.
N.A.
62.3
64.4
69.1
58
P-Site Identity:
100
13.3
100
93.3
N.A.
100
100
N.A.
73.3
N.A.
73.3
N.A.
N.A.
13.3
20
20
33.3
P-Site Similarity:
100
40
100
100
N.A.
100
100
N.A.
93.3
N.A.
86.6
N.A.
N.A.
33.3
40
46.6
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
36.6
46.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
53.3
63.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
8
0
0
58
0
0
0
8
15
8
0
0
0
% A
% Cys:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
50
0
8
0
8
0
0
8
8
0
0
% D
% Glu:
8
8
0
8
8
22
15
8
8
0
8
0
72
0
15
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
15
0
0
8
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% H
% Ile:
8
0
0
0
0
0
8
0
0
8
8
0
0
0
0
% I
% Lys:
72
0
15
43
0
0
65
15
72
65
8
0
8
29
65
% K
% Leu:
0
0
15
0
8
0
0
8
0
8
15
15
0
8
8
% L
% Met:
0
0
29
0
0
0
0
0
0
0
0
8
0
0
0
% M
% Asn:
0
8
0
0
15
0
0
8
0
0
0
0
0
0
0
% N
% Pro:
8
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
8
0
8
0
0
0
0
0
0
8
8
0
0
% Q
% Arg:
0
8
8
29
0
0
0
0
8
8
8
8
0
0
0
% R
% Ser:
8
15
22
0
0
22
0
8
0
8
0
0
8
50
0
% S
% Thr:
0
0
0
0
0
0
0
43
0
0
0
0
0
8
8
% T
% Val:
0
50
0
8
0
0
8
0
0
0
43
50
0
8
0
% V
% Trp:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _